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Table 1 Characteristics of anthracycline-exposed childhood cancer survivors

From: Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report

Variables

Cases (N = 32)

Controls (N = 32)

p-valuea

Age at primary cancer diagnosis in years

 Median (IQR)

9.5 (3.8–14.7)

10.7 (3.9–15.1)

0.71

Sex, N (%)

 Female

19 (59.4)

16 (50.0)

0.45

 Male

13 (40.6)

16 (50.0)

Cumulative anthracycline exposure, N (%)

 < 250 mg/m2

13 (40.6)

20 (62.5)

0.08

 ≥ 250 mg/m2

19 (59.4)

12 (37.5)

Chest Radiation

 Yes (N, %)

13 (40.6)

6 (18.8)

0.05

 Dose in cGy (Mean ± SD)

1335.6 ± 1953.7

524.1 ± 1185.5

0.044

Race/Ethnicity (N, %)

 Non-Hispanic white

15 (46.9)

15 (46.9)

Matched

 Hispanic

9 (28.1)

9 (28.1)

 Black/African American

5 (15.6)

5 (15.6)

 Asian

3 (9.4)

2 (6.3)

 Mixed race/ethnicity

0 (0.0)

1 (3.1)

Primary Diagnosis, N (%)

 Acute lymphoblastic leukemia

7 (21.9)

7 (21.9)

Matched

 Acute myeloid leukemia

2 (6.3)

2 (6.3)

 Ewing sarcoma

4 (12.5)

4 (12.5)

 Hodgkin lymphoma

4 (12.5)

4 (12.5)

 Neuroblastoma

4 (12.5)

4 (12.5)

 Non-Hodgkin lymphoma

5 (15.6)

5 (15.6)

 Osteosarcoma

4 (12.5)

4 (12.5)

 Soft tissue sarcoma

2 (6.3)

2 (6.3)

CVRF, N (%)

 No

18 (56.3)

31 (96.9)

0.0006

 Yes

12 (37.5)

1 (3.1)

 Missing

2 (6.3)

0 (0.0)

Time from diagnosis to cardiac event for cases or time to enrollment for controls in years

 Median (IQR)

2.4 (0.6–7.7)

9.4 (6.4–13.7)

0.0001

  1. Abbreviations: SD standard deviation, cGy centi-gray, IQR interquartile range, CVRF Cardiovascular Risk Factors
  2. aP-values were estimated using either chi‐square or Fisher exact test for categorical variables and the Wilcoxon/Kruskal–Wallis test for continuous variables
  3. Values in bold indicate statistical significance at P < 0.05