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Table 2 Coefficients and P-values for baseline and optimized logistic regression models predicting early and later cardio-inflammatory IrAEs

From: Time dependent predictors of cardiac inflammatory adverse events in cancer patients receiving immune checkpoint inhibitors

Variable

Baseline 3-Months

Optimized 3 Months

Baseline 3–12 Months

Optimized 3–12 Months

HR (95%CI)

coefficient (p-value)

HR (95%CI)

coefficient (p-value)

HR (95%CI)

coefficient (p-value)

HR (95%CI)

coefficient (p-value)

Myocarditis/Pericarditis History

Binary Variable (ref = No)

    

8.19 (1.95–23.10)

2.104 (0.0005)****

8.67 (2.08- 24.00)

2.16 (0.0003)****

Anti-PD-1 Agent

Binary Variable (Yes or No)

1.49 (0.97–2.34)

0.396 (0.081)*

1.48 (0.97–2.37)

0.395 (0.081)*

    

Combination Therapy

Binary Variable (ref = No)

4.66 (2.79–7.99)

1.541 (7.85e-9)****

4.67 (2.79–7.99)

1.54 (7.78e-9)****

1.56 (0.93–2.45)

0.444 (0.069)*

1.54 (0.92–2.43)

0.436 (0.075)*

Congestive Heart Failure

Binary Variable (ref = No)

1.14 (0.71–1.75)

0.128 (0.577)

  

1.15 (0.67–1.86)

0.138 (0.589)

  

Peripheral Vascular Disease

Binary Variable (ref = No)

1.54 (1.09–2.15)

0.432 (0.013)**

1.71 (1.23–2.34)

0.538 (0.0009)****

    

Cerebrovascular Disease

Binary Variable (ref = No)

1.12 (0.73–1.67)

0.115 (0.585)

  

1.99 (1.34–2.88)

0.689 (0.0004)****

2.06 (1.40- 3.00)

0.724 (0.0001)****

Hypertension

Binary Variable (ref = No)

1.17 (0.86–1.59)

0.155 (0.324)

  

0.966 (0.68–1.36)

-0.034 (0.844)

  

Diabetes Mellitus

Binary Variable (ref = No)

    

1.38 (0.95–1.98)

0.321 (0.088)*

1.42 (1.00–2.00)

0.352 (0.046)**

ACE-I

Binary Variable (ref = No)

    

1.60 (1.02–2.43)

0.467 (0.034)**

1.68 (1.10–2.48)

0.520 (0.012)**

Beta-Blocker

Binary Variable (ref = No)

    

1.05 (0.71–1.54)

0.052 (0.790)

  

Loop Diuretic

Binary Variable (ref = No)

    

1.16 (0.68–1.88)

0.152 (0.555)

  

Statin

Binary Variable (ref = No)

    

1.06 (0.79–1.49)

0.059 (0.769)

  

Aspirin

Binary Variable (ref = No)

1.23 (0.81–1.80)

0.205 (0.311)

      

Anti-Coagulant

Binary Variable (ref = No)

1.25 (0.93–1.68)

0.222 (0.136)

1.30 (0.97–1.75)

0.267(0.069)*

1.09 (0.79–1.49)

0.083 (0.605)

  

Atypical Anti-Psychotic

Binary Variable (ref = No)

1.67 (0.85–2.95)

0.513 (0.102)

1.70 (0.86- 3.00)

0.532 (0.089)*

    

Non-steroidal Anti-Inflammatory

Binary Variable (ref = No)

    

1.67 (1.18–2.32)

0.512 (0.003)***

1.71 (1.22–2.37)

0.538 (0.001)***

  1. Columns from left to right represent the variable name, and logistic regression metrics for the following models: baseline 3 months predictive model, optimized 3-month predictive model, baseline 3–12 month model, and the optimized 3–12 months model. Each entry has 2 lines, line 1 has associated hazard ratio and 95% confidence interval (HR, CI), and line 2 has the reported logistic regression coefficient and p-value. Asterisks next to P-values are indicators of potential significance, with 1 (*) being p-value less than 0.1, 2 (**) less than 0.05, (***) less than 0.01, (****) less than 0.001. Variable encoding for categorical
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Cardio-Oncology

ISSN: 2057-3804

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