Risk of coronary events 55 Years after Thymic irradiation in the Hempelmann cohort

Cardio-Oncology

Table 5 Incidence Rates of CHD events by Estimated Cardiac Radiation Dose from Hempelmann’s Thymic Irradiation Cohort

Dose (Gy)	Number of Persons	Person Years at Risk	Mean Dose Gy (Std Dev)	Median Dose (Gy)	MI Cases	MI Rate (per 10,000 p-yrs)	Rate Ratio of CHD Compared to Non-irradiated (95%CI)^a	Fully Adjusted Rate Ratio of CHD (95%CI)^b
Non-Irradiated	4833	213,024	–	–	206	9.67	Ref	Ref
Total Irradiated	2657	126,244	1.45 (1.28)	1.40	144	11.41	1.12 (0.90–1.39)	1.07 (0.86–1.32)
0.01–0.99	1058	45,659	0.55 (0.21)	0.25	22	4.82	0.81 (0.51–1.24)	1.14 (0.70–1.75)
1.00–1.99	923	43,533	1.59 (0.15)	1.56	51	11.72	1.28 (0.93–1.73)	1.26 (0.91–1.70)
2.00–2.99	323	17,735	2.45 (0.10)	2.46	33	18.61	1.17 (0.79–1.66)	0.96 (0.65–1.37)
3.00–20.99	229	12,486	4.28 (0.58)	4.00	29	23.23	1.31 (0.87–1.89)	1.10 (0.47–1.61)
Irradiated but dose unknown	124	6831	–	–	9	13.18	0.82 (0.39–1.51)	0.65 (0.31–1.20)
							Test of trend^c P = 0.07	Test of trend^d P > 0.50

Analysis was performed with the AMFIT module of Epicure on all 7490 subjects in the thymus irradiation group
^a Rate ratio is based on dose category model adjusted by attained age and sex
^b Fully adjusted rate ratio is based on a dose category model adjusted for attained age and sex, diabetes, dyslipidemia, ever smoked, and hypertension
^c Test for trend of rate ratios by dose categories. Excludes subjects in the unknown radiation dose category
^d Test for trend of rate ratios by dose categories adjusted for attained age, sex, diabetes, dyslipidemia, ever smoking, hypertension

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